Prevalence of pathogenic variants in cancer-predisposing genes in second cancer after childhood solid cancers.

Masanori YoshidaKazuhiko NakabayashiWentao YangAiko Sato-OtsuboShin-Ichi TsujimotoHiroko Ogata-KawataTomoko KawaiKeisuke IshiwataMika SakamotoKohji OkamuraKaoru YoshidaRyota ShiraiTomoo OsumiChikako KiyotaniYoko ShiodaKeita TerashimaSae IshimaruYuki YuzaMasatoshi TakagiYuki ArakawaToshihiko ImamuraDaisuke HasegawaAkiko InoueTakako YoshiokaShuichi ItoDaisuke TomizawaKatsuyoshi KohKimikazu MatsumotoNobutaka KiyokawaSeishi OgawaAtsushi ManabeAkira NiwaKenichiro HataJun J YangMotohiro Kato

Published in: Cancer medicine (2023)

We highlight that overlapping effects of genetic background and primary cancer treatment contribute to the development of second cancers after treatment of pediatric solid tumors. A comprehensive analysis of germline and tumor samples may be useful to predict the risk of secondary cancers.

Keyphrases

childhood cancer
papillary thyroid
squamous cell
genome wide
young adults
copy number
risk factors
lymph node metastasis
squamous cell carcinoma