Immune and genomic biomarkers of immunotherapy response in cancer of unknown primary.
Atara PosnerTharani SivakumaranAndrew PattisonDariush EtemadmoghadamNiko ThioColin WoodKrista FisherSamantha WebbAnna DeFazioNicholas WilckenBo GaoChristos S KarapetisMadhu SinghIan M CollinsGary RichardsonChristopher SteerMark WarrenNarayan KaranthAndrew FellowesStephen B FoxRodney J HicksPenelope SchofieldDavid BowtellOwen W J PrallRichard William TothillLinda MileshkinPublished in: Journal for immunotherapy of cancer (2023)
A significant fraction of CUP tumors had genomic features previously associated with ICI response. High IR score was the most sensitive predictive feature of ICI response, warranting evaluation in a larger patient series.