Poly (ADP-ribose) polymerase inhibitors sensitize cancer cells to hypofractionated radiotherapy through altered selection of DNA double-strand break repair pathways.

Yuji Seo Keisuke TamariYutaka TakahashiKazumasa Minami Shotaro TatekawaFumiaki IsohashiOsamu SuzukiYuichi AkinoKazuhiko Ogawa

Published in: International journal of radiation biology (2022)

PARPi may be a promising candidate to combine with stereotactic hypofractionated radiotherapy, aiming at high-dose region-directed radiosensitization.

Keyphrases

radiation therapy
high dose
locally advanced
brain metastases
early stage
radiation induced
low dose
small cell lung cancer
circulating tumor
stem cell transplantation
single molecule
cell free
squamous cell carcinoma
rectal cancer
structural basis
circulating tumor cells