Comparative efficacy of cephradine-loaded silver and gold nanoparticles against resistant human pathogens.
Ajmal KhanHumera JabeenTouqeer AhmadNajeeb Ur RehmanSaleha Suleman KhanHuma ShareefRizwana SarwarSaira YahyaNusrat HussainJalal UddinJavid HussainAhmed Al HarrasiPublished in: Artificial cells, nanomedicine, and biotechnology (2022)
Infections caused by drug-resistant bacteria are major health concerns worldwide. We successfully synthesized cephradine gold nanoparticles (Ceph-Au NPs) and cephradine silver nanoparticles (Ceph-Ag NPs) and compared their efficacy against resistant human pathogens. X-Ray diffraction (XRD), Atomic Force Microscopy (AFM) and Transmission Electron Microscopy (TEM) results showed that average particle size of Ceph-Au NPs and Ceph-Ag NPs were 7 and 12 nm, respectively. Fourier Transform Infra-red spectroscopy (FTIR) spectra revealed the conjugation of -NH 2 and -OH functional moieties with the nanoparticle (NP) surfaces. These NPs significantly inhibited the biofilm of Streptococcus mutans ( S. mutans) and methicillin-resistant Staphylococcus aureus (MRSA) in the range of 61.25-250 µg/mL. Ceph-Au NPs are more active than Ceph-Ag NPs and can be used to treat the diseases associated with MRSA and S. mutans.
Keyphrases
- methicillin resistant staphylococcus aureus
- gold nanoparticles
- biofilm formation
- staphylococcus aureus
- candida albicans
- drug resistant
- oxide nanoparticles
- reduced graphene oxide
- atomic force microscopy
- electron microscopy
- silver nanoparticles
- endothelial cells
- pseudomonas aeruginosa
- quantum dots
- multidrug resistant
- sensitive detection
- high resolution
- high speed
- healthcare
- public health
- visible light
- escherichia coli
- single molecule
- drug delivery
- gram negative
- mental health
- highly efficient
- computed tomography
- antimicrobial resistance
- social media
- induced pluripotent stem cells
- wound healing
- health information