Adding new experimental arms to randomised clinical trials: Impact on error rates.

Babak Choodari-OskooeiDaniel J BrattonMelissa R GannonAngela M MeadeMatthew Robert SydesMahesh Kb Parmar

Published in: Clinical trials (London, England) (2020)

The findings we present in this article can be used to design trials with pre-planned deferred arms or to add new pairwise comparisons within an ongoing platform trial where control of the pairwise error rate or familywise type I error rate (for a subset of pairwise comparisons) is required.

Keyphrases

clinical trial
phase ii
study protocol
phase iii
open label
double blind
high throughput
placebo controlled