FAPI-Negative FDG-Avid Metastatic Relapse of Breast Cancer on PET/CT.

A 69-year-old woman with breast cancer underwent 18F-FDG PET/CT because of the increased CA-15-3 level. 18F-FDG PET/CT showed multiple hypermetabolic lymph nodes (LNs) in the neck and mediastinum. The patient was also referred for 68Ga-fibroblast activation protein inhibitor (FAPI) 04 PET/CT for further evaluation. However, 18F-FDG-avid LNs were FAPI-negative on 68Ga-FAPI-04 PET/CT. Supraclavicular LN biopsy confirmed the metastasis of breast cancer. Recent reports have focused on the potential of FAPI PET imaging in breast cancer; however, this case highlights that false-negative 68Ga-FAPI-04-PET/CT findings should also be considered while evaluating metastatic spread.