Briarenones A‒C, New Briarellin Diterpenoids from the Gorgonian Briareum violaceum.
Yang ChengAtallah F AhmedRaha S OrfaliChang-Feng DaiJyh-Horng SheuPublished in: Marine drugs (2019)
Three new eunicellin-derived diterpenoids of briarellin type, briarenones A‒C (1‒3), were isolated from a Formosan gorgonian Briareum violaceum. The chemical structures of the compounds were elucidated on the basis of extensive spectroscopic analyses, including two-dimensional (2D) NMR. The absolute configuration of 1 was further confirmed by a single crystal X-ray diffraction analysis. The in vitro cytotoxic and anti-inflammatory potentialities of the isolated metabolites were tested against the growth of a limited panel of cancer cell lines and against the production of superoxide anions and elastase release in N-formyl-methionyl-leucyl-phenyl-alanine and cytochalasin B (fMLF/CB)-stimulated human neutrophils, respectively.
Keyphrases
- high resolution
- anti inflammatory
- endothelial cells
- papillary thyroid
- magnetic resonance
- molecular docking
- solid state
- ms ms
- hydrogen peroxide
- squamous cell
- induced pluripotent stem cells
- electron microscopy
- mass spectrometry
- young adults
- squamous cell carcinoma
- magnetic resonance imaging
- childhood cancer
- lymph node metastasis
- nitric oxide