pH-responsive molecular assemblies of pyridylbutadiene derivative with cucurbit[7]uril.
Anuji K VasuRaman KhuranaJyotirmayee MohantySriram KanvahPublished in: RSC advances (2018)
The interaction between red-emitting pyridinium derivative [4-((1 E ,3 E )-4-(4-(dimethylamino)phenyl)buta-1,3-dien-1-yl)-1-methylpyridin-1-ium] (DABP) and cucurbit[7]uril was investigated using optical absorption, steady-state and time-resolved fluorescence and anisotropy measurements. The changes in the UV/Vis absorption, fluorescence spectral characteristics and lifetime, with a change in pH, reveal efficient binding of CB7 to the dye molecule. The cucurbit[7]uril encapsulated DABP brings ∼1.5 units upward p K a shift. The formation of supramolecular assemblies with 1 : 1 and 2 : 1 host-guest stoichiometries with CB7 at different pH conditions have been verified from 1 H NMR, isothermal titration calorimetric studies and geometry optimization calculations. CB7-dye complexation and the ensuing morphological changes were revealed by SEM, AFM and optical microscopy images. This pH-responsive supramolecular assemblies of red-emitting DABP dye can find potential applications in biological imaging, optical pH-sensor and the construction of building blocks for the supramolecular architectures.
Keyphrases
- energy transfer
- high resolution
- high speed
- water soluble
- atomic force microscopy
- quantum dots
- single molecule
- optical coherence tomography
- highly efficient
- aqueous solution
- mass spectrometry
- deep learning
- gene expression
- molecular dynamics simulations
- convolutional neural network
- magnetic resonance imaging
- molecular dynamics
- density functional theory
- photodynamic therapy
- human health
- transcription factor
- dna binding
- binding protein
- fluorescence imaging