Lipoxin A4 depresses inflammation and promotes autophagy via AhR/mTOR/AKT pathway to suppress endometriosis.

Zhi-Xiong HuangXiao-Rong HeXin-Yu DingJia-Hao ChenYi-Hong LeiJian-Bing BaiDian-Chao LinYi-Huang HongJian-Fa LanQiong-Hua Chen

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2022)

In endometriosis, increased inflammation of ectopic lesions prominently depresses autophagy. LXA4 could regulate autophagy by suppressing inflammatory response through AhR/AKT/mTOR pathway.

Keyphrases

oxidative stress
signaling pathway
cell proliferation
cell death
inflammatory response
endoplasmic reticulum stress
lipopolysaccharide induced
immune response
toll like receptor