Postmenopausal women are overrepresented in the preserved ejection heart failure population. Expansion of visceral and epicardial adipose tissue during the menopause transition leads to local and low-grade systemic inflammation that in turn contributes to left ventricular concentric remodeling, diastolic dysfunction and the development and progression of preserved ejection fraction. In contrast to visceral adipose tissue imaging, epicardial adipose tissue can be inexpensively imaged on low radiation coronary calcium score computerized tomography examination. The menopause transition provides a unique time frame to evaluate the contribution of epicardial adipose tissue expansion to the pathogenesis of preserved ejection heart failure.
Keyphrases
- ejection fraction
- adipose tissue
- postmenopausal women
- heart failure
- aortic stenosis
- insulin resistance
- left ventricular
- low grade
- bone mineral density
- high fat diet
- cardiac resynchronization therapy
- high grade
- hypertrophic cardiomyopathy
- acute myocardial infarction
- acute heart failure
- coronary artery disease
- metabolic syndrome
- skeletal muscle
- atrial fibrillation
- coronary artery
- type diabetes
- high resolution
- magnetic resonance
- mitral valve
- transcatheter aortic valve replacement
- fluorescent probe
- computed tomography
- blood pressure
- electronic health record
- living cells
- left atrial
- fluorescence imaging
- percutaneous coronary intervention