Distinct transcriptional profiles of Leptospira borgpetersenii serovar Hardjo strains JB197 and HB203 cultured at different temperatures.

Ellie J PutzSathesh K SivasankaranLuis G V FernandesBrian BrunelleJohn D LippolisDavid P AltDarrell O Bayles Richard L Hornsby Jarlath E Nally

Published in: PLoS neglected tropical diseases (2021)

Investigation of the L. borgpetersenii JB197 and HB203 transcriptome provides unique insight into the mechanistic differences between acute and chronic disease. Characterizing the nuances of strain to strain differences and investigating the environmental sensitivity of Leptospira to temperature is critical to the development and progress of leptospirosis prevention and treatment technologies, and is an important consideration when serovars are selected and propagated for use as bacterin vaccines as well as for the identification of novel therapeutic targets.

Keyphrases

gene expression
liver failure
escherichia coli
endothelial cells
rna seq
respiratory failure
transcription factor
single cell
genome wide
drug induced
human health
intensive care unit
hepatitis b virus
acute respiratory distress syndrome
mechanical ventilation
heat stress