Hypoxia-inducible factor 3α1 increases epithelial-to-mesenchymal transition and iron uptake to drive colorectal cancer liver metastasis.

Luke B VillarealDaniel M FalconLiwei XieXiang Xue

Published in: British journal of cancer (2024)

HIF-3α1 plays a critical role in colon cancer progression by promoting EMT, iron accumulation, and metastasis through ZEB2 and TFRC regulation, suggesting potential therapeutic targets in CRC.

Keyphrases

epithelial mesenchymal transition
iron deficiency
endothelial cells
human health
climate change