Multiple clinically relevant immunotherapies prolong the function of microencapsulated porcine islet xenografts in diabetic NOD mice without the use of anti-CD154 mAb.
Susan A SafleyGraham F BarberRobert W HoldcraftLawrence S GazdaStephanie DuncansonMark C PoznanskyAthanassios SambanisCollin J WeberPublished in: Xenotransplantation (2020)
Multiple different immunotherapies which specifically inhibit CD4+ T cells, modulate T-cell trafficking, or interfere with antigen presentation can substitute for anti-CD154 mAb to prolong encapsulated islet xenograft function in diabetic NOD mice.