A photoactivated H 2 S donor based on a coumarin structure with real-time monitoring capability.

Attaining controlled, biocompatible H 2 S donors poses significant challenges. We developed Bhc-TCN-Ph, a photoactivated H 2 S donor derived from 6-bromo-7-hydroxycoumarinmethyl thiocarbonate. Upon 365 nm light exposure, COS is released, generating H 2 S and coumarin fluorescence for visualization. This process produces no electrophilic by-products. In vitro evaluations reveal good cytochemical and cytocompatibility characteristics.