Platelet Internalization Mediates Ferroptosis in Myocardial Infarction.

Shuo MiaoQingsong ZhangWei DingBo HouZhe SuMengyang LiLanting YangJun ZhangWenguang ChangJian-Xun Wang

Published in: Arteriosclerosis, thrombosis, and vascular biology (2022)

Our work reveals a novel mechanism of platelet-mediated myocardial injury, highlighting antiplatelet therapies could potentially represent a multimechanism treatment of myocardial infarction, and implying ferroptosis being considered as novel target for therapeutics.

Keyphrases

cell death
heart failure
left ventricular
small molecule
combination therapy
replacement therapy