IL23R gene variants in relation to IL17A levels and clinical phenotype in patients with ankylosing spondylitis.

Johannes Cornelis NossentSylvia Sagen-JohnsenGunnstein Bakland

Published in: Rheumatology advances in practice (2018)

Homozygosity for rs11209026A is rare in AS patients, but may ameliorate the clinical presentation. IL17A and IL23 levels are similar in controls and AS patients. IL23R variants influence IL23 levels but not IL17A levels in AS patients, suggesting that IL23R impacts more on cell types other than Th17 cells.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
prognostic factors
copy number
rheumatoid arthritis
stem cells
gene expression
induced apoptosis
mesenchymal stem cells
cell death
genome wide
transcription factor
cell therapy