Multiple airborne allergen-induced eosinophilic chronic rhinosinusitis murine model.

Sang Chul ParkSoo In KimChi Sang HwangHyung-Ju ChoJoo-Heon YoonChang Hoon Kim

Published in: European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (2019)

We successfully established a new murine model of ECRS using more clinically relevant multiple airborne allergens. Prolonged exposure to airborne allergens for 12 weeks or more, corresponding to the definition of human ECRS, strongly induced eosinophil infiltration as well as epithelial remodeling.

Keyphrases

chronic rhinosinusitis
particulate matter
high glucose
endothelial cells
diabetic rats
drug induced
air pollution
oxidative stress
allergic rhinitis