Leveraging Therapy-Specific Polygenic Risk Scores to Predict Restrictive Lung Defects in Childhood Cancer Survivors.
Cindy ImMenglu CheEric D AustinDennis C StokesMatthew J KrasinAndrew M DavidoffYadav SapkotaZhaoming WangKristen K NessCarmen L WilsonGregory T ArmstrongMelissa M HudsonLeslie L RobisonDaniel A MulrooneyYutaka YasuiPublished in: Cancer research (2022)
This study develops a therapy-specific polygenic risk prediction model to more precisely identify childhood cancer survivors at high risk for pulmonary complications, which could help improve risk stratification for other late effects.