Effects of metformin administration on endocrine-metabolic parameters, visceral adiposity and cardiovascular risk factors in children with obesity and risk markers for metabolic syndrome: A pilot study.
Judit BassolsJosé-María Martínez-CalcerradaInés OsiniriFerran Díaz-RoldánSilvia Xargay-TorrentBerta Mas-ParésEstefanía Dorado-CeballosAnna Prats-PuigGemma Carreras-BadosaFrancis de ZegherLourdes IbáñezAbel López-BermejoPublished in: PloS one (2019)
In this pilot study, metformin treatment in pre-puberal and early pubertal children with obesity seemed to improve body composition and inflammation markers. Our data encourage the development of future fully powered trials using 850 mg/day metformin in young children, highlighting its excellent tolerance and potential long-term benefits.
Keyphrases
- metabolic syndrome
- cardiovascular risk factors
- insulin resistance
- body composition
- young adults
- high fat diet induced
- weight gain
- resistance training
- weight loss
- uric acid
- type diabetes
- bone mineral density
- adipose tissue
- oxidative stress
- skeletal muscle
- cardiovascular disease
- electronic health record
- body mass index
- physical activity
- high intensity
- big data