CD155 blockade enhances allogeneic natural killer cell-mediated antitumor response against osteosarcoma.
Monica M ChoLongzhen SongAicha E QuamineFernanda SzewcLei ShiAmy K ErbeJonathan D EbbenDavid P TuricekJillian M KlineEmily O LafeberMadison F PhillipsAmanda S CeasPaul M SondelChristian M CapitiniPublished in: bioRxiv : the preprint server for biology (2023)
These results demonstrate efficacy of allogeneic NK cells combined with CD155 blockade to mount an antitumor response against CD155-expressing OS. Translation of combination adoptive NK cell and CD155 axis modulation offers a platform for alloBMT treatment approaches for pediatric patients with relapsed and refractory solid tumors.