5-Hydroxymethylation highlights the heterogeneity in keratinization and cell junctions in head and neck cancers.
Siyu LiuMarcell Costa de MedeirosEvan M FernandezKatie R ZarinsRaymond G CavalcanteTingting QinGregory T WolfMaria E FigueroaNisha J D'SilvaLaura S RozekMaureen A SartorPublished in: Clinical epigenetics (2020)
Our results implicate 5hmC in driving differences in keratinization, cell junctions and other cancer-related processes among tumor subtypes. We conclude that 5hmC levels are critical for defining tumor characteristics and potentially used to define clinically meaningful cancer patient subgroups.