Reduced arterial compliance along the cerebrovascular tree predicts cognitive slowing in multiple sclerosis: Evidence for a neurovascular uncoupling hypothesis.
Dinesh K SivakolunduKathryn L WestGayathri B MaruthyMark ZuppichiniMonroe P TurnerDema AbdelkarimYuguang ZhaoDylan NguyenJeffrey S SpenceHanzhang LuDarin T OkudaBart RypmaPublished in: Multiple sclerosis (Houndmills, Basingstoke, England) (2019)
Such associations suggest prospects for utility of ACI in predicting future cognitive disturbances, monitoring cognitive deficiencies and therapeutic responses, and implicates neurovascular uncoupling as a mechanism of cognitive slowing in MS.