Disseminated thymic B-cell lymphoma in a Holstein heifer.
Wan N A D HishamnuriShotaro NakagunMasaki MaezawaKana SakaguchiNao AkiyamaKen-Ichi WatanabeNoriyuki HoriuchiYoshiyasu KobayashiHisashi InokumaPublished in: Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc (2019)
A 19-mo-old Holstein heifer was inactive and dyspneic. Physical examination revealed wheezing, exophthalmos, a cervical mass, and lymphadenopathy. Cytology of the cervical mass and lymph nodes showed predominantly large atypical lymphocytes. Lactate dehydrogenase and thymidine kinase activities were elevated. Although nested PCR for bovine leukemia virus (BLV) using blood was positive, quantitative PCR showed a low number of provirus copies. Autopsy revealed enlargement of most lymph nodes examined, as well as white masses of various sizes in muscles of the left hindlimb and thoracic and abdominal organs. Histopathology revealed severe infiltration with neoplastic lymphocytes in these organs. The cervical mass was immune-positive for B-cell markers. The final diagnosis was thymic B-cell lymphoma with BLV infection.
Keyphrases
- lymph node
- fine needle aspiration
- single cell
- diffuse large b cell lymphoma
- peripheral blood
- heat stress
- ultrasound guided
- spinal cord
- sentinel lymph node
- mental health
- neoadjuvant chemotherapy
- physical activity
- high grade
- high resolution
- bone marrow
- spinal cord injury
- magnetic resonance
- magnetic resonance imaging
- computed tomography
- early stage
- contrast enhanced
- locally advanced