Whole-exome Sequencing of Nigerian Prostate Tumors from the Prostate Cancer Transatlantic Consortium (CaPTC) Reveals DNA Repair Genes Associated with African Ancestry.
Jason A WhiteErnest T KaninjingKayode A AdenijiPaul JibrinJohn Oladapo ObafunwaChidiebere N OgoMohammed FarukAdemola Alabi PopoolaOmolara A FatiregunOlabode P OluwoleBalasubramanyanam KaranamIsra ElhussinStefan AmbsWei TangMelissa B DavisPaz PolakMoray J CampbellKathryn R BrignoleSolomon O RotimiWindy Dean-ColombFolakemi T OdedinaDamali N MartinClayton C YatesPublished in: Cancer research communications (2022)
MAA have higher rates of prostate cancer incidence and mortality, however, are severely underrepresented in genomic studies. This is the first study utilizing whole-exome sequencing in NG men to identify West African ancestry-linked variant patterns that impact DNA damage repair pathways.