Network Pharmacology, Molecular Docking Analysis and Experiment Validations on Molecular Targets and Mechanisms of the Dispel-Scar Ointment in Scar Treatment.

Zhaoyi LiYi CaoHui LiSihua LeLibo Yin

Published in: Combinatorial chemistry & high throughput screening (2024)

Network pharmacology, molecular docking, and experimental validation showed DSO&amp;#039;s potential in treating scars. It may inhibit scars via the TGF-β1/SMADs/MMPs signalling pathway, providing a basis for DSO&amp;#039;s scar treatment application.

Keyphrases

molecular docking
protein kinase
molecular dynamics simulations
transforming growth factor
risk assessment
signaling pathway