Phosphate Dysregulation and Metabolic Syndrome.
Nikolay MironovMainul HaqueAzeddine AtfiMohammed Shawkat RazzaquePublished in: Nutrients (2022)
Phosphorus is one of the most abundant minerals in the human body. It is essential for almost all biochemical activities through ATP formation, intracellular signal transduction, cell membrane formation, bone mineralization, DNA and RNA synthesis, and inflammation modulation through various inflammatory cytokines. Phosphorus levels must be optimally regulated, as any deviations may lead to substantial derangements in glucose homeostasis. Clinical studies have reported that hyperphosphatemia can increase an individual's risk of developing metabolic syndrome. High phosphate burden has been shown to impair glucose metabolism by impairing pancreatic insulin secretion and increasing the risk of cardiometabolic disorders. Phosphate toxicity deserves more attention as metabolic syndrome is being seen more frequently worldwide and should be investigated further to determine the underlying mechanism of how phosphate burden may increase the cardiometabolic risk in the general population.
Keyphrases
- metabolic syndrome
- insulin resistance
- uric acid
- oxidative stress
- endothelial cells
- cardiovascular risk factors
- risk factors
- working memory
- type diabetes
- cardiovascular disease
- transcription factor
- single molecule
- blood pressure
- induced pluripotent stem cells
- atomic force microscopy
- risk assessment
- skeletal muscle
- bone loss
- body composition