Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity.

Etsuro NanishiFrancesco BorrielloTimothy R O'MearaMarisa E McGrathYoshine SaitoRobert E HauptHyuk-Soo SeoSimon D van HarenByron BrookJing ChenJoann Diray-ArceSimon Doss-GollinMaria De LeonKatherine ChewManisha MenonKijun SongAndrew Z XuTimothy M CaradonnaJared Feldman Blake M HauserAaron G SchmidtAmy C ShermanLindsey R BadenRobert K ErnstCarly DillenStuart M WestonRobert M JohnsonHolly L HammondRomana MayerAllen BurkeMaria E BottazziPeter J HotezUlrich StrychAiquan ChangJingyou YuDan H BarouchSirano Dhe-PaganonIvan ZanoniAl OzonoffMatthew B FriemanOfer Levy David J Dowling

Published in: bioRxiv : the preprint server for biology (2021)

Alum and CpG enhance SARS-CoV-2 RBD protective immunity, variant neutralization in aged mice and Th1-polarizing cytokine production by human elder leukocytes.

Keyphrases

sars cov
endothelial cells
dna methylation
high glucose
respiratory syndrome coronavirus
induced pluripotent stem cells
high fat diet induced
early stage
oxidative stress
peripheral blood
cancer therapy
drug induced
skeletal muscle