XRCC5/6 polymorphisms and their interactions with smoking, alcohol consumption, and sleep satisfaction in breast cancer risk: A Chinese multi-center study.

Li-Xiang YuLi-Yuan LiuYu-Juan XiangFei WangFei ZhouShu-Ya HuangChao ZhengChun-Miao YeWen-Zhong ZhouGeng-Shen YinJia-Lin ZhangShu-De CuiFu-Guo TianZhi-Min FanCui-Zhi GengXu-Chen CaoZhen-Lin YangXiang WangHong LiangShu WangHong-Chuan JiangXue-Ning DuanHai-Bo WangGuo-Lou LiQi-Tang WangJian-Guo ZhangFeng JinJin-Hai TangLiang LiShi-Guang ZhuWen-Shu ZuoZhong-Bing MaZhi-Gang Yu

Published in: Cancer medicine (2021)

XRCC5 rs16855458 was associated with breast cancer risk, and XRCC6 rs2267437 was associated with the risk of ER-/PR- breast cancer. Breast cancer risk associated with XRCC5 and XRCC6 polymorphisms might vary according to alcohol consumption and sleep satisfaction, respectively, and merit further investigation.

Keyphrases

breast cancer risk
alcohol consumption
dna repair
dna damage
physical activity
sleep quality
smoking cessation
depressive symptoms
endoplasmic reticulum