Myopathy as a cause of fatigue in long-term post-COVID-19 symptoms: Evidence of skeletal muscle histopathology.
Eva K HejbølThomas HarboJane AgergaardLine B MadsenThomas H PedersenLars J ØstergaardHenning AndersenHenrik D SchrøderHatice TankisiPublished in: European journal of neurology (2022)
The wide variety of histological changes in this study suggests that skeletal muscles may be a major target of SARS-CoV-2, causing muscular post-COVID-19 symptoms. The mitochondrial changes, inflammation, and capillary injury in muscle biopsies can cause fatigue in part due to reduced energy supply. Because most patients had mild-moderate acute affection, the new variants that might cause less severe acute disease could still have the ability to cause long-term myopathy.
Keyphrases
- sars cov
- skeletal muscle
- coronavirus disease
- sleep quality
- end stage renal disease
- oxidative stress
- respiratory syndrome coronavirus
- newly diagnosed
- late onset
- ejection fraction
- liver failure
- chronic kidney disease
- prognostic factors
- insulin resistance
- peritoneal dialysis
- copy number
- metabolic syndrome
- physical activity
- hepatitis b virus
- body composition
- patient reported outcomes