Direct oral anticoagulants versus vitamin K antagonists after recent ischemic stroke in patients with atrial fibrillation.

David Julian SeiffgeMaurizio PaciaroniDuncan WilsonMasatoshi KogaKosmas MachaManuel CappellariSabine SchaedelinClare ShakeshaftMasahito TakagiGeorgios K TsivgoulisBruno BonettiBernd KallmünzerShoji ArihiroAndrea AlbertiAlexandros A PolymerisGareth AmblerSohei YoshimuraMichele VentiLeo H BonatiKeith W MuirHiroshi YamagamiSebastian ThilemannRiccardo AltavillaNils PetersManabu InoueTobias BobingerGiancarlo AgnelliMartin M BrownShoichiro SatoMonica AcciarresiHans Rolf JagerPaolo BoviStefan SchwabPhilippe LyrerValeria CasoKazunori ToyodaDavid J WerringStefan T EngelterGian Marco De Marchisnull null

Published in: Annals of neurology (2019)

DOAC treatment commenced early after recent cerebral ischemia related to AF was associated with reduced risk of poor clinical outcomes compared to VKA, mainly attributed to lower risks of ICH. ANN NEUROL 2019;85:823-834.

Keyphrases

direct oral anticoagulants
atrial fibrillation
cerebral ischemia
venous thromboembolism
subarachnoid hemorrhage
brain injury
blood brain barrier
risk assessment
combination therapy