Phenotyping Study of Cyclophosphamide 4-Hydroxylation in Malay Cancer Patients.

Yesi Ihdina Fityatal Hasanah Yahdiana Harahap Denni Joko Purwanto

Published in: Drug design, development and therapy (2021)

Phenotyping study of CP 4-hydroxylation in Malay cancer patients can be conducted by quantifying CP bioactivity ratio (4-OHCP to CP level) in dried blood spot. In majority of Malay cancer patients, cyclophosphamide would be bioactivated through 4-hydroxylation in hepar rapidly as indicated by the high value of the bioactivity ratio or the increased CP clearance and 4-OHCP level.

Keyphrases

low dose
high dose
high throughput