Preemptive intrathecal administration of endomorphins relieves inflammatory pain in male mice via inhibition of p38 MAPK signaling and regulation of inflammatory cytokines.

Ting ZhangNan ZhangRun ZhangWeidong ZhaoYong ChenZilong WangBiao XuMengna ZhangXuerui ShiQinqin ZhangYuanyuan GuoJian XiaoDan ChenQuan Fang

Published in: Journal of neuroinflammation (2018)

Our findings reveal a novel mechanism by which preemptive treatment of endomorphins attenuates inflammatory pain through regulating the production of inflammatory cytokines in DRG neurons via inhibition of p38 MAPK phosphorylation.

Keyphrases

chronic pain
pain management
neuropathic pain
oxidative stress
spinal cord
genome wide
single cell
gene expression
spinal cord injury
smoking cessation