Unique brain injury patterns after proton vs photon radiotherapy for WHO grade 2-3 gliomas.

Sebastian F WinterMelissa M GardnerPhilipp KarschniaEugene J VaiosClemens GrassbergerMarc R BussièreKatarina NikolicThanakit PongpitakmethaFelix EhretDavid KaulWolfgang Boehmerle Matthias EndresHelen A ShihMichael W ParsonsJorg Dietrich

Published in: The oncologist (2024)

CNS radiotoxicity is common and progressive in glioma patients. Injury patterns suggest radiation modality-specificity as RIL, TN, and CMB exhibit unique spatiotemporal differences following XRT vs PRT, likely reflecting underlying dosimetric and radiobiological differences. Familiarity with such injury patterns is essential to improve patient management. Prospective studies are needed to validate these findings and assess their impacts on neurocognitive function.

Keyphrases

brain injury
subarachnoid hemorrhage
radiation therapy
end stage renal disease
ejection fraction
newly diagnosed
early stage
multiple sclerosis
radiation induced
prognostic factors
case report
blood brain barrier
cerebral ischemia
locally advanced
monte carlo
rectal cancer
case control
fluorescent probe