Proteoglycan-4 is an essential regulator of synovial macrophage polarization and inflammatory macrophage joint infiltration.

Marwa QadriGregory D JayLing X ZhangTannin A SchmidtJennifer TotonchyKhaled A Elsaid

Published in: Arthritis research & therapy (2021)

PRG4 regulates the accumulation and homeostatic balance of macrophages in the synovium. In its absence, the synovium becomes populated with M1 macrophages. Furthermore, macrophages exert an effector role in synovial fibrosis in Prg4GT/GT animals.

Keyphrases

adipose tissue
oxidative stress
transcription factor
regulatory t cells
immune response