Interleukin-18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis.

Jana KnorrBenedikt KaufmannMaria Eugenia InzaugaratTheresa Maria HoltmannLukas GeislerJana HundertmarkMarlene Sophia KohlheppLaela M BoosheriDaisy R Chilin-FuentesAmanda BirminghamKathleen M FischJoel D SchillingSven H LoosenChristian TrautweinChristoph RoderburgMünevver DemirFrank TackeHal M HoffmanAriel E FeldsteinAlexander Wree

Published in: Hepatology (Baltimore, Md.) (2022)

Our study highlights the role of IL-18 in the development of liver fibrosis by its direct effect on HSC activation identifying IL-18 as a target to treat liver fibrosis.

Keyphrases

liver fibrosis
induced apoptosis
cell cycle arrest
oxidative stress
pi k akt