Active immunisation targeting nerve growth factor attenuates chronic pain behaviour in murine osteoarthritis.

Isabell S von Loga Aadil El TurabiLuke JostinsJadwiga Miotla-ZarebskaJennifer Mackay-AldersonAndris ZeltinsIda ParisiMartin F BachmannTonia L Vincent

Published in: Annals of the rheumatic diseases (2019)

This study demonstrates therapeutic efficacy of a novel NGF vaccine strategy that reversibly alleviates spontaneous pain behaviour in surgically induced murine OA.

Keyphrases

growth factor
chronic pain
pain management
knee osteoarthritis
rheumatoid arthritis
high glucose
diabetic rats
mouse model
drug induced
cancer therapy
oxidative stress
drug delivery
endothelial cells
peripheral nerve