LINC00571 drives tricarboxylic acid cycle metabolism in triple-negative breast cancer through HNRNPK/ILF2/IDH2 axis.

Zihan XiHaohao HuangJin HuYuanhang YuXianxiong MaMing XuJie MingLei LiHui ZhangHengyu ChenTao Huang

Published in: Journal of experimental & clinical cancer research : CR (2024)

Our study revealed that the LINC00571/HNRNPK/ILF2/IDH2 axis promoted the progression of triple-negative breast cancer by regulating tricarboxylic acid cycle metabolites. This discovery provides a novel theoretical foundation and new potential targets for the clinical treatment of triple-negative breast cancer.

Keyphrases

long non coding rna
long noncoding rna
cell proliferation
low grade
small molecule
ms ms
single cell
wild type
combination therapy
climate change
high grade