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Single-neuron correlate of epilepsy-related cognitive deficits in visual recognition memory in right mesial temporal lobe.

Seung J LeeDanielle E BeamAndrea G P SchjetnanLynn K PaulNand ChandravadiaChrystal M ReedJeffrey M ChungIan B RossTaufik A ValianteAdam N MamelakUeli Rutishauser
Published in: Epilepsia (2021)
Together, these findings show that single-cell responses can be used to assess the causal effects of local circuit disruption by an SOZ in the MTL, and establish a neural correlate of cognitive impairment due to epilepsy that can be used as a biomarker to assess the efficacy of novel treatments.
Keyphrases
  • temporal lobe epilepsy
  • cognitive impairment
  • single cell
  • rna seq
  • working memory
  • high throughput
  • drug induced