Absence of disruptive TP53 mutations in high-risk human papillomavirus-driven neck squamous cell carcinoma of unknown primary.
Paolo Boscolo RizzoLea SchroederValeria SacchettoDana HolzingerMaria Cristina Da MostoGiancarlo TirelliElisa Dal CinMonica MantovaniAnna MenegaldoAnnarosa Del MistroSalvatore RomeoAngelo Paolo Dei TosMonia NieroStefania RigoGerhard DyckhoffJochen HessLaia AlemanyMiquel QuerXavier Leon VintroJerry PoleselMichael PawlitaRoberta BertorellePublished in: Head & neck (2019)
In a fraction of cases, NSCCUP is an HPV-driven entity harboring wild-type TP53 gene or nondisruptive TP53 mutations. HPV-driven NSCCUP might benefit from treatment de-intensification.