The clinical application of random flaps in wound repair has been a topic of discussion. Random flaps are prone to necrosis due to the lack of well-defined vascular blood supply during transfer surgery. Their clinical utility is restricted, financial and psychological burdens is imposed on patients due to this limitation. The survival of random skin flaps depends on factors such as ischemia-reperfusion injury, oxidative stress, local inflammatory response, and neovascularization. This review aims to provide an overview of the evidence supporting the use of random flaps in clinical practice. In addition, this review explores the impact of different medications on signaling pathways within the flap's local microcirculation and investigates the interconnections between these pathways.
Keyphrases
- soft tissue
- breast reconstruction
- oxidative stress
- ischemia reperfusion injury
- inflammatory response
- end stage renal disease
- clinical practice
- signaling pathway
- minimally invasive
- chronic kidney disease
- newly diagnosed
- wound healing
- peritoneal dialysis
- induced apoptosis
- healthcare
- epithelial mesenchymal transition
- coronary artery disease
- coronary artery bypass
- percutaneous coronary intervention
- lipopolysaccharide induced
- acute coronary syndrome
- endothelial cells
- lps induced
- endoplasmic reticulum stress
- heat stress
- drug induced