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PD-L1, CD4+, and CD8+ Tumor-Infiltrating Lymphocytes (TILs) Expression Profiles in Melanoma Tumor Microenvironment Cells.

Bogdan Marian CarabanElena MateiGeorgeta Camelia CozaruMariana AşchieMariana DeacuManuela EnciuGabriela Isabela BaltatescuAnca ChisoiNicolae DobrinLucian PetcuEmma GheorgheLaurențiu-Tony HanganMihai Cătălin RoșuCristian Ionuț OrasanuAnca Antonela Nicolau
Published in: Journal of personalized medicine (2023)
(1) Background: Because melanoma is an aggressive tumor with an unfavorable prognosis, we aimed to characterize the PD-L1 expression in melanomas in association with T cell infiltrates because PD-1/PD-L1 blockade represents the target in treating melanoma strategy. (2) Methods: The immunohistochemical manual quantitative methods of PD-L1, CD4, and CD8 TILs were performed in melanoma tumor microenvironment cells. (3) Results: Most of the PD-L1 positive, expressing tumors, have a moderate score of CD4+ TILs and CD8+TILs (5-50% of tumor area) in tumoral melanoma environment cells. The PD-L1 expression in TILs was correlated with different degrees of lymphocytic infiltration described by the Clark system (X 2 = 8.383, p = 0.020). PD-L1 expression was observed often in melanoma cases, with more than 2-4 mm of Breslow tumor thickness being the associated parameters (X 2 = 9.933, p = 0.014). (4) Conclusions: PD-L1 expression represents a predictive biomarker with very good accuracy for discriminating the presence or absence of malign tumoral melanoma cells. PD-L1 expression was an independent predictor of good prognosis in patients with melanomas.
Keyphrases
  • induced apoptosis
  • cell cycle arrest
  • skin cancer
  • nk cells
  • endoplasmic reticulum stress
  • high resolution
  • cell proliferation
  • mass spectrometry