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Neurological symptoms in Hypophosphatasia.

J M ColazoJ R HuK M DahirJill H Simmons
Published in: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2018)
The extra-skeletal manifestations of HPP, specifically neurological symptoms, have not been previously well documented. However, mental health diagnoses and neurological symptoms such as headache and sleep disturbance occur commonly in patients with HPP. The recognition of non-traditional symptoms in HPP may improve patient satisfaction, preempt costly evaluation and misdiagnosis, and may lead to further treatment options.
Keyphrases
  • sleep quality
  • mental health
  • patient satisfaction
  • physical activity
  • cerebral ischemia
  • blood brain barrier
  • brain injury
  • replacement therapy
  • subarachnoid hemorrhage