Low-dose radiation therapy for osteoarthritis and enthesopathies: a review of current data.
Seyed Alireza JavadiniaNooshin NazeminezhadRuhollah Ghahramani-AslDavood SorooshDanial Fazilat-PanahBabak PeyroShabanySeyedeh Naeimeh SaberhosseiniArezoo MehrabianFarzad Taghizadeh-HesaryMohammad NematshahiGaurav DhawanJames S WelshEdward J CalabreseRachna KapoorPublished in: International journal of radiation biology (2021)
Several single-arm retrospective/prospective studies showed advantages for LD-RT in the management of OA in terms of pain relief, improvement of mobility and function, and showed minimal side effects. Mechanistic considerations involve positive subcellular effects mediated by the activation of a nuclear factor erythroid 2-related transcription factor (Nrf2) mediated antioxidant response. Further research on both the short- and long-term effects of LD-RT on OA and other inflammatory disorders is recommended.