Multi-omics colocalization with genome-wide association studies reveals a context-specific genetic mechanism at a childhood onset asthma risk locus.

Marcus M SoliaiAtsushi KatoBritney A HellingCatherine T StanhopeJames E NortonKatherine A NaughtonAiko I KlingerEmma E ThompsonSelene M ClaySoyeon KimJuan C CeledónJames E GernDaniel J JacksonMatthew C AltmanRobert C KernBruce K TanRobert P SchleimerDan L NicolaeJayant M PintoCarole Ober

Published in: Genome medicine (2021)

This study provides evidence of functional effects for asthma risk variants in AECs and insight into RV-mediated transcriptional and epigenetic response mechanisms that modulate genetic effects in the airway and risk for asthma.

Keyphrases

chronic obstructive pulmonary disease
lung function
gene expression
copy number
mycobacterium tuberculosis
genome wide association
genome wide
transcription factor
single cell
cystic fibrosis
heat shock protein