miR-18a reactivates the Epstein-Barr virus through defective DNA damage response and promotes genomic instability in EBV-associated lymphomas.

Pengfei CaoMeili ZhangLujuan WangBuqing SaiJiuqi TangZhaohui LuoCijun ShuaiLiyang ZhangZheng LiYanjin WangGuiyuan LiJuanjuan Xiang

Published in: BMC cancer (2018)

Taken together, these results indicate that DNA-damaging agents and host microRNAs play roles in EBV reactivation. Our study supported the interplay between host cell DDR, environmental genotoxic stress and EBV.

Keyphrases

epstein barr virus
dna damage response
diffuse large b cell lymphoma
cell proliferation
long non coding rna
single cell
dna repair
circulating tumor
cell free
gene expression
dna methylation
dna damage
human health
nucleic acid
heat stress
mesenchymal stem cells