"Ears of the Lynx" MRI Sign Is Associated with SPG11 and SPG15 Hereditary Spastic Paraplegia.
Maria B PascualSusanne T de BotM R DanielsMarcondes Cavalcante de França JuniorC ToroMario RiverolPeter HederaMaria Teresa BassiNereo BresolinBart P C Van De WarrenburgB KremerJ NicolaiPerrine CharlesJiaqiong XuS SinghN J PatronasSteve H FungMichael D GregoryJoseph C MasdeuPublished in: AJNR. American journal of neuroradiology (2019)
The ears of the lynx sign on FLAIR MR imaging is highly specific for the most common genetic subtypes of hereditary spastic paraplegia with a thin corpus callosum. When this sign is present, there is a high likelihood of a genetic mutation, particularly associated with SPG11 or SPG15, even in the absence of a family history.