The combination of olaratumab with gemcitabine and docetaxel arrests a chemotherapy-resistant undifferentiated soft-tissue sarcoma in a patient-derived orthotopic xenograft mouse model.

Takashi HiguchiKentaro MiyakeNorihiko SugisawaHiromichi OshiroZhiying ZhangSahar RazmjooeiNorio YamamotoKatsuhiro HayashiHiroaki KimuraShinji MiwaKentaro IgarashiMichael BouvetShree Ram SinghHiroyuki TsuchiyaRobert M Hoffman

Published in: Cancer chemotherapy and pharmacology (2019)

The present study demonstrates the power of the PDOX model to identify the novel effective treatment strategy of the combination of OLA, GEM and DOC for drug-resistant soft-tissue sarcoma.

Keyphrases

drug resistant
locally advanced
multidrug resistant
mouse model
acinetobacter baumannii
squamous cell carcinoma
cystic fibrosis
cardiac arrest
smoking cessation