Cpd-42 Alleviates Acute Kidney Injury via Targeting RIPK3-mediated Necroptosis.
Xiao-Yan HeFang WangXiao-Guo SuoMing-Zhen GuJia-Nan WangChuan-Hui XuYu-Hang DongYuan HeYao ZhangMing-Lu JiYing ChenMeng-Meng ZhangYin-Guang FanJia-Gen WenJuan JinJie WangJun LiChun-Lin ZhuangMing-Ming LiuXiao-Ming MengPublished in: British journal of pharmacology (2023)
As a novel RIPK3 inhibitor, Cpd-42 reduced kidney damage, inflammatory response, and necroptosis in AKI by binding to sites Thr94 and Ser146 on RIPK3 and might be a promising treatment for AKI.