Elevated plasma level of Pentraxin 3 is associated with emphysema and mortality in smokers.
Yingze ZhangJohn TedrowMehdi NouraieXiaoyun LiDivay ChandraJessica BonDaniel J KassCarl R FuhrmanJoseph K LeaderSteven R DuncanNaftali KaminskiFrank C SciurbaPublished in: Thorax (2021)
These data show strong and overlapping associations of lung and blood PTX3 levels, and PTX3 regulatory gene variants, with the severity of airflow obstruction, emphysema and mortality among smokers. These findings have potential implications regarding the pathogenesis of smoking-related lung diseases and warrant further exploration for the use of PTX3 as a predictive biomarker.
Keyphrases
- smoking cessation
- chronic obstructive pulmonary disease
- cardiovascular events
- copy number
- lung function
- risk factors
- idiopathic pulmonary fibrosis
- pulmonary fibrosis
- transcription factor
- genome wide
- electronic health record
- cardiovascular disease
- gene expression
- coronary artery disease
- big data
- machine learning
- genome wide identification
- air pollution
- climate change
- deep learning