Synthesis of chiral (tetrazolyl)methyl-containing acrylates via silicon-induced organocatalytic kinetic resolution of Morita-Baylis-Hillman fluorides.

Takayuki NishimineHiromi TairaSatoru MoriOkiya MatsubaraEtsuko TokunagaHidehiko AkiyamaVadim A SoloshonokNorio Shibata

Published in: Chemical communications (Cambridge, England) (2018)

Reported herein is a new approach for the asymmetric installation of a (tetrazolyl)methyl group via Si/F activation using organocatalytic kinetic resolution of racemic MBH-fluorides.

Keyphrases

single molecule
high glucose
diabetic rats
drug induced
ionic liquid
endothelial cells
stress induced